| Autor: |
Osborn, Helen M. I., Evans, Philip G., Gemmell, Natasha, Osborne, Sadie D. |
| Zdroj: |
Journal of Pharmacy and Pharmacology; June 2004, Vol. 56 Issue: 6 p691-702, 12p |
| Abstrakt: |
In recent years there has been a resurgence of interest in the biological roles of carbohydrates and as a result it is now known that carbohydrates are involved in a vast array of disease processes. This review summarises progress in the development of carbohydrate‐based therapeutics that involve: inhibition of carbohydrate‐lectin interactions; immunisation, using monoclonal antibodies for carbohydrate antigens; inhibition of enzymes that synthesise disease‐associated carbohydrates; replacement of carbohydrate‐processing enzymes; targeting of drugs to specific disease cells via carbohydrate‐lectin interactions; carbohydrate based anti‐thrombotic agents. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Plný text