| Autor: |
Okoyeh, J. N., Lege‐Oguntoye, L., Ugbode, R. O., Ogunrinde, G. O. |
| Zdroj: |
Tropical Medicine & International Health; April 1997, Vol. 2 Issue: 4 p319-324, 6p |
| Abstrakt: |
SummaryThirty‐three children aged 6 months to 7 years from an area with multidrug‐resistant Plasmodium falciparum strains were treated with 25 mg/kg body weight of mefloquine base as a single oral dose. They were followed‐up using the modified 28‐day WHO extended field test. The parasite isolates from these patients were cultured in vitrowith different concentrations of mefloquine. All children were parasite‐negative by day 4, and 31 remained so throughout the period of observation. Two patients who were parasitaemic on days 16 and 28 were successfully treated with a sulphadoxine/pyrimethamine combination. Parasitological and clinical responses were well correlated. The mean parasite clearance time was 65 ± 10.2 hours. A mefloquine concentration of 64 pmol/well inhibited schizont growth and the EC50and EC99were 5.5 and 54 pmol/well (1.1 and 10.8 μmol/l blood) respectively. This indicates reduced parasite susceptibility to the drug in vitro. |
| Databáze: |
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