Pharmacokinetic Interactions between HIV‐1 Protease Inhibitors in Rats: Study on Combinations of Two Kinds of HIV‐1 Protease Inhibitors

Autor: SHIBATA, NOBUHITO, MATSUMURA, YASUHIRO, OKAMOTO, HIROYUKI, KAWAGUCHI, YUKO, OHTANI, AKIKO, YOSHIKAWA, YUKAKO, TAKADA, KANJI
Zdroj: Journal of Pharmacy and Pharmacology; October 2000, Vol. 52 Issue: 10 p1239-1246, 8p
Abstrakt: The drug interactions between four human immune deficiency virus (HIV‐1) protease inhibitors have been characterized by in‐vitro metabolic studies using rat liver microsomal fractions and in‐vivo oral administration. In this study, a new HPLC analytical method developed by us was used for the simultaneous determination of saquinavir and nelfinavir in rat plasma and microsomes.
Databáze: Supplemental Index