Prolonged T1values of the crushed nerve are not exclusively attributable to Wallerian degeneration or endoneurial edema

Autor: Ribari, Samo, Jarh, Orest, Sepe, Ana, Demsar, Franci
Zdroj: Restorative Neurology and Neuroscience; January 1992, Vol. 4 Issue: 6 p363-368, 6p
Abstrakt: Axonotmesis of the left sciatic nerve was performed on adult male Wistar rats. T1values of the crushed nerve samples were determined with proton magnetic resonance spectroscopy. Denervation changes of the dependent hind plantar flexor muscles were assessed with proton magnetic resonance imaging of their cross-sectional area and muscle force measurements. However, Tlrelaxation time of the crushed nerve samples remained prolonged implying the absence of nerve regeneration. This would be in contradiction with what is known about regeneration after simple crash and the muscle force and magnetic resonance imaging measurements of the dependent plantar flexor muscles. These studies indicated that sufficient nerve regeneration had taken place to restore their muscle force and volume. A model is suggested to explain the persistence of prolonged Tlvalues in the presence of muscle force recovery.
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