| Autor: |
Zarge, Joseph I., Husak, Vicki, Huang, Peter, Greisler, Howard P. |
| Zdroj: |
The American Journal of Surgery; 1997, Vol. 174 Issue: 2 p188-192, 5p |
| Abstrakt: |
Background: The early success rates of endarterectomy and angioplasty are influenced by the thrombogenicity of the deendothelialized surface. We previously reported decreased platelet deposition after 30 and 120 minutes and after 28 days on expanded polytetrafluoroethylene (ePTFE) grafts coated with fibrin glue (FG) containing fibroblast growth factor type 1 (FGF-1) and heparin in canine aortoiliac bypass grafts when compared with control uncoated grafts. The FG/FGF-1/heparin coating has been shown to enhance spontaneous endothelialization at 28 days in canine e-PTFE bypass grafts. The current study evaluates the thrombogenicity of this FG/FGF-1/heparin suspension applied to a balloon de-endothelialization model of endarterectomy in canine carotid arteries. |
| Databáze: |
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| Externí odkaz: |
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