| Autor: |
LI, QI‐GUI, PEGGINS, JAMES O., FLECKENSTEIN, LAWRENCE L., MASONIC, KELLY, HEIFFER, MELVIN H., BREWER, THOMAS G. |
| Zdroj: |
Journal of Pharmacy and Pharmacology; February 1998, Vol. 50 Issue: 2 p173-182, 10p |
| Abstrakt: |
The pharmacokinetics and bioavailability of dihydroartemisinin (DQHS), artemether (AM), arteether (AE), artesunic acid (AS) and artelinic acid (AL) have been investigated in rats after single intravenous, intramuscular and intragastric doses of 10 mg kg−1. Plasma was separated from blood samples collected at different times after dosing and analysed for parent drug. Plasma samples from rats dosed with AM, AE, AS and AL were also analysed for DQHS which is known to be an active metabolite of these compounds. |
| Databáze: |
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