| Autor: |
Stemmer-Rachamimov, Anat O., Wiederhold, Thorsten, Nielsen, G. Petur, James, Marianne, Pinney-Michalowski, Denise, Roy, Jennifer E., Cohen, Wendy A., Ramesh, Vijaya, Louis, David N. |
| Zdroj: |
American Journal of Pathology; January 2001, Vol. 158 Issue: 1 p57-62, 6p |
| Abstrakt: |
NHE-RF, a regulatory cofactor for NHE (Na+-H+exchanger) type 3, interacts with ion transporters and receptors through its PDZ domains and with the MERM proteins (merlin, ezrin, radixin and moesin) via its carboxyl terminus. Thus, NHE-RF may act as a multifunctional adaptor protein and play a role in the assembly of signal transduction complexes, linking ion channels and receptors to the actin cytoskeleton. NHE-RF expression is up-regulated in response to estrogen in estrogen receptor-positive breast carcinoma cell lines, suggesting that it may be involved in estrogen signaling. To further understand NHE-RF function and its possible role in estrogen signaling, we analyzed NHE-RF expression in normal human tissues, including cycling endometrium, and in breast carcinomas, tissues in which estrogen plays an important role in regulating cell growth and proliferation. NHE-RF is expressed in many epithelia, especially in cells specialized in ion transport or absorption, and is often localized to apical (luminal) membranes. NHE-RF expression varies markedly in proliferative versussecretory endometrium, with high expression in proliferative (estrogen-stimulated) endometrium. Furthermore, estrogen receptor status and NHE-RF expression correlate closely in breast carcinoma specimens. These findings support a role for NHE-RF in estrogen signaling. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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