| Autor: |
Duffy, K. J., Price, A. T., Delorme, E., Dillon, S. B., Duquenne, C., Erickson-Miller, C., Giampa, L., Huang, Y., Keenan, R. M., Lamb, P., Liu, N., Miller, S. G., Rosen, J., Shaw, A. N., Smith, H., Wiggall, K. J., Zhang, L., Luengo, J. I. |
| Zdroj: |
Journal of Medicinal Chemistry; August 2002, Vol. 45 Issue: 17 p3576-3578, 3p |
| Abstrakt: |
The invention of a new class of naphtho[1,2-d]imidazole thrombopoietin mimics based on a pharmacophore hypothesis for small-molecule thrombopoietic agonists is discussed. Parallel array synthesis and purification techniques allowed for the rapid exploration of structure−activity relationships within this class and for the improvement in TPO mimetic potencies and efficacies. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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