| Autor: |
Arslanian, R. L., Tang, L., Blough, S., Ma, W., Qiu, R.-G., Katz, L., Carney, J. R. |
| Zdroj: |
Journal of Natural Products; July 2002, Vol. 65 Issue: 7 p1061-1064, 4p |
| Abstrakt: |
A new epothilone, 10,11-didehydroepothilone D (5), was isolated from a strain of the heterologous host Myxococcus xanthus genetically engineered to produce epothilone D (4). The structure of 5 was determined from NMR and MS data. The epothilone polyketide synthase was further modified in a recombinant M. xanthus strain to produce 5 as the major epothilone-related metabolite. The cytotoxicity of 5 against a panel of tumor cell lines, including several with multidrug resistance, and its effect on tubulin polymerization were comparable to epothilone D (4). |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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