| Autor: |
Pursch, Matthias, Sun, Kefu, Winniford, Bill, Cortes, Hernan, Weber, Andy, McCabe, Terry, Luong, Jim |
| Zdroj: |
Analytical and Bioanalytical Chemistry; July 2002, Vol. 373 Issue: 6 p356-367, 12p |
| Abstrakt: |
More than a decade after Phillips' first published work this article reviews recent developments in comprehensive two-dimensional gas chromatography (GC×GC). Special attention is devoted to the further development and diversity of modulation devices. These include heated sweepers, cryofocused modulators, and a variety of diaphragm valve-switching strategies. It is demonstrated that all modulation approaches can be very well suited to GC×GC, depending on the particular application. Diaphragm-valve modulation is very powerful for volatile organic compounds. Slotted heater and cryofocused modulation are preferred for samples that contain non-volatile components. Applications ranging from petroleum to environmental and biological samples are illustrated. Extension of the technique to GC×GC–mass spectrometry (MS) is also discussed and trends for future research activity are pointed out. |
| Databáze: |
Supplemental Index |
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