| Autor: |
Defraites, Robert F., Feighner, Brian H., Binn, Leonard N., Kanjarpane, Devesh D., Delem, Andree D., Macarthy, Philip O., Krauss, Margot R., Krause, David S., Moonsammy, George I., Charles H. Hoke Jr., And |
| Zdroj: |
The Journal of Infectious Diseases; March 1995, Vol. 171 Issue: Supplement 1 pS61-S61, 1p |
| Abstrakt: |
To study the feasibility of using inactivated hepatitis A vaccine for rapid immunization of US soldiers, 276 randomized seronegative volunteers received one of four regimens: two injections, on day 0 or one each on day 0 and 14, day 0 and 30, or day 0 and 180. A third dose was given on day 380. Among the 256 recipients of two doses, 99% responded with antibody (by ELISA) with few symptoms. A higher percentage of recipients of both doses on day 0 had antibody at day 14 (68% vs. 52% of all others, P < .03). The highest antibody concentrations (711 mIU/mL on day 240) were observed in subjects given a second dose on day 180. Recipients of the third injection developed a median IS-fold rise in antibody within 2 weeks. Virus-neutralizing antibody was detected in high titers after the third dose and neutralized strains of hepatitis A virus from several countries. Vaccines containing 1440 ELISA units of antigen may be useful for rapid immunization. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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