Association between single-nucleotide polymorphisms of selected genes involved in the response to DNA damage and risk of colon, head and neck, and breast cancers in a Polish population

Autor: Jelonek, K., Gdowicz-Kłosok, A., Pietrowska, M., Borkowska, M., Korfanty, J., Rzeszowska-Wolny, J., Widłak, P.
Zdroj: Journal of Applied Genetics; September 2010, Vol. 51 Issue: 3 p343-352, 10p
Abstrakt: Single-nucleotide polymorphisms in genes involved in DNA-damage-induced responses are reported frequently to be a risk factor in various cancer types. Here we analysed polymorphisms in 5 genes involved in DNA repair (XPDAsp312Asn and Lys751Gln,XRCC1Arg399Gln,APE1Asp148Glu,NBS1Glu185Gln, andXPAG-4A) and in a gene involved in regulation of the cell-cycle (CCND1A870G). We compared their frequencies in groups of colon, head and neck, and breast cancer patients, and 2 healthy control groups: (1) matched healthy Polish individuals and (2) a NCBI database control group. Highly significant differences in the distribution of genotypes of theAPE1, XRCC1andCCND1genes were found between colon cancer patients and healthy individuals. The 148AspAPE1allele and the 399GlnXRCC1allele apparently increased the risk of colon cancer (OR=1.9–2.3 and OR=1.5–2.1, respectively). Additionally, frequencies ofXPDgenotypes differed between healthy controls and patients with colon or head and neck cancer. Importantly, no differences in the distribution of these polymorphisms were found between healthy controls and breast cancer patients. The data clearly indicate that the risk of colon cancer is associated with single-nucleotide polymorphism in genes involved in base-excision repair and DNA-damage-induced responses.
Databáze: Supplemental Index
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