Synthesis of Orthogonally Protected Bis(aminomethyl)malonic Acid, and Its Use as a Key Building Block in the Preparation of Cyclic Peptide Conjugates of 2-N-Alkyl-1,2,3,4-tetrahydroisoquinoline on a Solid Support

Autor: Virta, Pasi, Rosenberg, Jaana, Karskela, Tuomas, Heinonen, Petri, Lönnberg, Harri
Zdroj: European Journal of Organic Chemistry; September 2001, Vol. 2001 Issue: 18 p3467-3473, 7p
Abstrakt: Orthogonally protected bis(aminomethyl)malonic acid (1) was synthesized and used as a key building block for the construction of cyclic peptide conjugates on a solid support. The applicability of the building block was demonstrated by preparation of 19 backbone cyclized/branched peptide conjugates of N-2-alkyl-5-(3-aminopropoxy)-1,2,3,4-tetrahydroisoquinoline as stereoisomeric pairs.
Databáze: Supplemental Index
Externí odkaz: