| Autor: |
Sanikidze, T., Tkhilava, N., Papava, M., Datunashvili, I., Gongadze, M., Gamrekelashvili, D., Bakhutashvili, V. |
| Zdroj: |
Bulletin of Experimental Biology and Medicine; February 2006, Vol. 141 Issue: 2 p211-215, 5p |
| Abstrakt: |
Abstract: We studied molecular mechanisms of changes in oxidative metabolism under conditions of experimental lipopolysaccharide-induced endotoxemia. Generation of reactive nitrogen and oxygen species in mice increased 18 h after treatment with lipopolysaccharide. These changes contributed to inactivation of enzymes and enzyme complexes (ribonucleotide reductase, NADH-ubiquinone oxidoreductase, and cytochrome c oxidase), dysfunction of the mitochondrial electron transport chain, and development of oxidative stress. Plaferon LB protected mice from the toxic effect of lipopolysaccharide. |
| Databáze: |
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