| Autor: |
Chaux, Pascal, Lethé, Bernard, Snick, Jacques Van, Corthals, Jurgen, Schultz, Erwin S., Cambiaso, César L., Boon, Thierry, Bruggen, Pierre van der |
| Zdroj: |
European Journal of Immunology; June 2001, Vol. 31 Issue: 6 p1910-1916, 7p |
| Abstrakt: |
Antigens encoded by MAGE genes and recognized by T cells are of interest for cancer immunotherapy because of their strict tumoral specificity and because they are shared by many tumors. Several MAGE-1 peptide that are recognized by CD8+ cytolytic T lymphocytes have been used in therapeutic vaccination trials. To obtain anti-tumor immune response, vaccines combining peptides recognized by CD8+ and peptides recognized by CD4+ T cells might be optimal. We focused therefore on the identification of MAGE peptides recognized by CD4+ T cells. We report here the identification of MAGE-1 epitope EYVIKVSARVRF, which is presented to CD4+ T lymphocytes by HLA-DR15. This HLA allele is present in 29 % of Asians and 17 % of Caucasians. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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