| Autor: |
Lee, Yong Ho, Nakamura, Tatsuo, Shimizu, Yasuhiko, Yamamoto, Yasumich, Kiyotani, Tetsuya, Tsuda, Touru, Teramachi, Masayoshi, Takimoto, Yukinobu |
| Zdroj: |
Journal of Biomedical Materials Research Part A; January 2003, Vol. 64 Issue: 1 p88-92, 5p |
| Abstrakt: |
We prepared a complex membrane consisting of human amnionderived collagen membrane and polyglycolic acid PGA, and then gelatin was crosslinked using heat on one side of the complex membrane to prepare a membrane that can prevent adhesion gelatinprocessed PGA–human collagen membrane. Applying this membrane to a rabbit cecumabdominalwalladhesion model, the prevention of adhesion and tissue regeneration were investigated. The animals were sacrificed 2 and 12 weeks after surgery and then examined. The adhesion scores in the shortterm observation group 2 weeks after surgery and longterm observation group 12 weeks after surgery were 1.0 ± 2.4 and 0.8 ± 2.0, respectively, showing a significant prevention of adhesion compared to the control value of 6.3 ± 2.5 p< 0.01. Histologically, gelatin was not absorbed, and outgrowth of connective tissue accompanied by capillary blood vessels was observed between the sample and the cecum in the shortterm observation group. In the longterm observation group, the sample was completely absorbed, and serous membrane was regenerated on the surface of connective tissue. Based on these findings, it is possible to use gelatinprocessed PGA–human collagen membrane as a filling material with both an adhesionpreventing effect and tissueregenerating function. © 2002 Wiley Periodicals, Inc. J Biomed Mater Res 64A: 88–92, 2003 |
| Databáze: |
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