| Autor: |
De Maeyer, Erna A. P., Verbeeck, Ronald M. H., Vercruysse, Chris W. J. |
| Zdroj: |
Journal of Biomedical Materials Research; October 2000, Vol. 52 Issue: 1 p95-106, 12p |
| Abstrakt: |
This study investigated the in vitroconversion reaction in calcium phosphate cements CPCs containing octacalcium phosphate OCP as one of the reagents. OCP is known to be a precursor for apatite formation in vivo. The reaction products were characterized using infrared spectroscopy and Xray diffraction. Although the conversion of OCP into hydroxyapatite is thermodynamically favorable, OCP only yields apatite formation in CPC provided it is combined with a highly soluble Ca2and OH−releasing reaction partner. In this respect, tetracalcium phosphate is a promising compound. Adding small amounts of monocalcium phosphate monohydrate can stimulate the setting through intermediate brushite formation. The preparation method of OCP might drastically affect the performance of the cement. The reaction path of the setting of these CPC probably does not conform to the singular point principle described in the literature, and an in situhydrolysis of OCP to apatite is conceivable. Simulation of apatite formation using OCP as the precursor andor seed in CPC might be beneficial for some biomedical applications. © 2000 John Wiley & Sons, Inc. J Biomed Mater Res, 52, 95–106, 2000. |
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