| Abstrakt: |
The osseointegration and longterm success of boneinterfacing implants are dependent on mechanical stability of the implant relative to host bone during the early healing period. The geometric design of an implant surface may play an important role in affecting early implant stabilization, possibly by influencing tissue healing dynamics. In this study, we compared the early tissue healing response and resulting implant stability for two surface designs by characterizing the histological and mechanical properties of the healing tissue around Ti6Al4V sintered poroussurfaced and Ti plasmasprayed implants. The implants were inserted transversely in rabbit femoral condyles and evaluated at 0, 4, 8, and 16 days postimplantation. At 4 and 8 days after implantation, the early healing tissue fibrin and collagenous matrix was more extensively integrated with the threedimensional interconnected structure of the sintered porous surface than with the irregular geometry of the plasmasprayed coating. In addition, histological examination indicated that initial matrix mineralization leading to osseointegration occurred more rapidly with the poroussurfaced implants. The more extensive tissue integration and more rapid matrix mineralization with the poroussurfaced implants were reflected in the mechanical test data, which demonstrated greater attachment strength and interfacial stiffness for the poroussurfaced implants 4 and 8 days postimplantation p< .05. Sixteen days after implantation, both implant designs were osseointegrated and had comparable attachment characteristics. These data demonstrate that appropriate surface design selection can improve early implant stability and induce an accelerated healing response, thereby improving the potential for implant osseointegration. © 1999 John Wiley & Sons, Inc. J Biomed Mater Res, 47, 127–138, 1999. |
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