| Abstrakt: |
To assess the histologic reaction caused by biomaterial particles in different sizes around the bone–implant interface, we examined ultrahigh molecular weight polyethylene UHMWPE, average diameter of 11 μm, UHMWPE 99 μm, cobaltchromium alloy CoCr, 3.9 μm, stainless steel SUS316L, 3.9 μm, alumina ceramics 3.9 μm, titanium alloy Ti, 3.5 μm, CoCr 0.03 μm, and Ti 0.03 μm. After the longitudinal groove on a polymethylmethacrylate plug was filled with one type of the particles, the plug was inserted into the medullar canal of the distal end of rabbit femurs, and tissue block was resected 4 and 12 weeks after the insertion. Histiocytes were markedly accumulated around the particles of UHMWPE 11 μm, CoCr 3.9 μm, SUS316L 3.9 μm, CoCr 0.03 μm, and titanium alloy 0.03 μm. Around the UHMWPE particles 99 μm, a slight histiocytic reaction and bone formation were observed. Particles of alumina ceramics 3.9 μm and titanium alloy 3.5 μm which were in phagocytosable sizes also had few histiocytic reactions. Statistically, the material difference was more strongly related to the histiocyte reaction than to the particle size and calculated total surface area of particles. Our findings demonstrate that particles of different biomaterials and in different sizes induce different foreignbody histological reactions. © 1999 John Wiley & Sons, Inc. J Biomed Mater Res, 45, 363–369, 1999. |
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