| Autor: |
Herczegh, P., Buxton, T. B., McPherson, J. C., III, Kovacs-Kulyassa, A., Brewer, P. D., Sztaricskai, F., Stroebel, G. G., Plowman, K. M., Farcasiu, D., Hartmann, J. F. |
| Zdroj: |
Journal of Medicinal Chemistry; May 2002, Vol. 45 Issue: 11 p2338-2341, 4p |
| Abstrakt: |
Bisphosphonates conjugated to fluoroquinolone antibacterials through an intermediate carbon had better activity than conjugates lacking the carbon. Virtually all molar-based activity of these esterified bisphosphonate derivatives was identical to that of its parent. De-esterified free-acid forms retained good activity against most Gram-negative bacteria, but not against Gram-positives. A free-acid derivative remained bound to washed bone and completely inhibited Staphylococcus aureus growth. The more potent parent, ciprofloxacin, failed to bind significantly, and bacterial growth occurred. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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