| Autor: |
Kolovou, Genovefa, Yiannakouris, Nikos, Hatzivassiliou, Marilena, Malakos, John, Daskalova, Deliana, Hatzigeorgiou, George, Cariolou, Marios A., Cokkinos, Dennis V. |
| Zdroj: |
Current Medical Research and Opinion; May 1, 2002, Vol. 18 Issue: 3 p118-124, 7p |
| Abstrakt: |
SummaryStudies in several populations have indicated that genetic variation at the apolipoprotein E (apoE) structural locus influences the risk of coronary artery disease (CAD) and myocardial infarction (MI). This study aimed at investigating whether apoE polymorphism has an allelic and/or genotypic impact on the risk of MI in Greek patients with CAD. We compared apoE gene polymorphism in a group of patients with angiographically confirmed CAD but not MI [CAD/MI (–)-group, n 143] and a group of age and sex-matched CAD patients who had experienced a non-fatal MI [CAD/MI ()-group, n 124]. The patients were also compared with a group of healthy younger individuals (n 240) with no family history of CAD.The apoE genotype distribution differed significantly between the two groups of CAD patients (p 0.02). The 2 allele was 5.3-fold less frequent in the CAD/MI ()-group compared with the CAD/MI (-)-group (1.2 vs. 6.3, p 0.01). The frequency of the 2 allele in healthy subjects was 8.1, which is 6.8-fold higher than in CAD/MI ()-patients (p 0.001) and twice as high compared with all CAD patients (p 0.02). No differences in 4 allele frequencies were observed between CAD/MI ()- and CAD/MI (–)-patients (10.9 vs. 9.8), or between patients with CAD and healthy subjects (10.3 vs. 10.2).In summary, the 4 allele was not found to be associated with an increased risk for CAD or MI. In contrast, a negative association of the 2 allele with MI was observed among Greek patients with CAD. |
| Databáze: |
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