Improved Process for the Preparation of 1-Benzhydrylazetidin-3-ol: Development of an Efficient Synthesis and Identification of Process-related Impurities and/or Intermediates

Autor: Reddy, V. V. R. M. Krishna, Babu, K. Kishore, Ganesh, A., Srinivasulu, P., Madhusudhan, G., Mukkanti, K.
Zdroj: Organic Process Research & Development; 20240101, Issue: Preprints
Abstrakt: An improved, one-pot, and multikilogram-scale synthesis of 1-benzhydrylazetidin-3-ol, the pharmaceutically important moiety, has been developed. The improved process for the preparation of 1-benzhydrylazetidin-3-ol was able to minimize a content of impurities and allows the effective production of 1-benzhydrylazetidin-3-ol and its scale-up. The process was high yielding (80%) and chromatography-free with purity 99.3 area %.
Databáze: Supplemental Index