| Autor: |
Dixon, Darryl D., Sethumadhavan, Divakaramenon, Benneche, Tore, Banaag, April R., Tius, Marcus A., Thakur, Ganesh A., Bowman, Anna, Wood, JodiAnne T., Makriyannis, Alexandros |
| Zdroj: |
Journal of Medicinal Chemistry; 20240101, Issue: Preprints |
| Abstrakt: |
The aliphatic side chain plays a pivotal role in determining the cannabinergic potency of tricyclic classical cannabinoids. We have synthesized a series of analogues in which the C3 position is substituted either directly or through a one-carbon atom linker with an adamantylamine or with an oxa- or an oxazaadamantane. The oxaadamantane pharmacophore in analogue 16showed the best binding profile for both receptors. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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