| Autor: |
Gluck, Gilbert, Anguelova, Tatiana, Heimark, Douglas, Larner, Joseph |
| Zdroj: |
Current Bioactive Compounds; June 2010, Vol. 6 Issue: 2 p90-96, 7p |
| Abstrakt: |
d-chiro-inositol (DCI) and manganese were administered orally singly and together to streptozotocin (STZ)- induced diabetic rats for 21 days and blood glucose values and body weights determined. At blood glucose values above 500 mg/dL, values were unchanged with DCI, manganese sulfate, or both over ten days. Insulin was administered to reduce the hyperglycemia to approximately 300 mg/dL. Over 12 days, DCI alone significantly reduced blood glucose (23), and the combination of DCI and manganese sulfate reduced hyperglycemia even more effectively (40) as compared to control animals. Of further interest, body weights both of female and male rats administered DCI and manganese were reduced, with females 25 compared to controls and males 21 compared to controls over the 21-day period. Metabolic mechanisms of actions of DCI and manganese to explain these results are discussed. |
| Databáze: |
Supplemental Index |
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