Studies on the Biosynthesis of Phomoidride B (CP-263,114):  Evidence for a Decarboxylative Homodimerization Pathway

Autor: Sulikowski, G. A., Agnelli, F., Spencer, P., Koomen, J. M., Russell, D. H.
Zdroj: Organic Letters; May 2002, Vol. 4 Issue: 9 p1447-1450, 4p
Abstrakt: Feeding experiments using a deuterium labeled C16 maleic anhydride and whole cell culture of ATCC 74256 led to the isolation of phomoidride B with deuterium incorporation at C(7) and C(19) as determined by 2H NMR and electrospray mass spectrometry. This result is in accord with a decarboxylative homodimerization of the C16 maleic anhydride as a key biosynthetic step leading to phomoidride B.
Databáze: Supplemental Index