| Autor: |
Penzotti, J. E., Lamb, M. L., Evensen, E., Grootenhuis, P. D. J. |
| Zdroj: |
Journal of Medicinal Chemistry; April 2002, Vol. 45 Issue: 9 p1737-1740, 4p |
| Abstrakt: |
P-glycoprotein (P-gp) functions as a drug efflux pump, mediating multidrug resistance and limiting the efficacy of many drugs. Clearly, identification of potential P-gp substrate liability early in the drug discovery process would be advantageous. We describe a multiple-pharmacophore model that can discriminate between substrates and nonsubstrates of P-gp with an accuracy of 63%. The application of this filter allows large virtual libraries to be screened efficiently for compounds less likely to be transported by P-gp. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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