A Strategy for the Synthesis of Aryl α-Ketoamides Based upon the Acylation of Anions Derived from Cyanomethylamines Followed by Oxidative Cleavage

Autor:	Yang, Z., Zhang, Z., Meanwell, N. A., Kadow, J. F., Wang, T.
Zdroj:	Organic Letters; April 2002, Vol. 4 Issue: 7 p1103-1105, 3p
Abstrakt:	Cyanomethylamines, prepared by alkylation of amines with chloroacetonitrile, were deprotonated using NaHDMS in THF, reacted with heteroaryl or substitutedphenyl esters, and then oxidized by adding CloroxTM to afford aryl α-ketoamides in a single operation in good overall yields.
Databáze:	Supplemental Index
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