Synthesis and antimicrobial activity of 2acyl or carboxyalkyl3H or alkyl or aryl5 or 6 or 8monochloro, 7fluorosubstituted4H1,4benzothiazines

Autor: Armenise, Domenico, De Laurentis, Nicolino, Rosato, Antonio, Morlacchi, Flaviano
Zdroj: Journal of Heterocyclic Chemistry; September 2006, Vol. 43 Issue: 5 p1371-1378, 8p
Abstrakt: A series of 2acyl or carboxyalkyl3H or alkyl or aryl5 or 6 or 8monochloro, 7fluorosubstituted4H1,4benzothiazines 3axwere prepared to investigate their potential biological activity. In this work the 3awstructures are supported with physical and analytical data and the results of their in vitroantimicrobial activity against some strains Gram positive, Gram negative, and Fungi are reported. It was found that compounds 3a, 3ddisplayed interesting antibacterial activity, whereas compound 3fdisplayed interesting antifungal activity.
Databáze: Supplemental Index