| Abstrakt: |
Basicity and alkaline hydrolysis of 1,2diaryl1H4,5,6,7tetrahydro1,3diazepines 1 are studied. Results are analyzed on the basis of Hammett and SwainLupton constants, finding good structurebasicity correlation when both, inductive and mesomeric effects, are considered together. Regioselectivity is observed in the alkaline hydrolysis of compounds 1, and it is analyzed in light of the stereoelectronic control theory. Results are compared with those previously obtained for five and six membered ring homologues: 1H4, 5dihydroimidazoles and 1,4,5,6tetrahydropyirimidines respectively. |
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