Pyridopyrimidines. X. Synthesis of 3Substituted 2Thioxo5,7dimethylpyrido2,3d pyrimidin43Hones and their SAlkylation Under Phase Transfer Conditions

Autor: Dave, Chaitanya G., Patel, Killol J.
Zdroj: Journal of Heterocyclic Chemistry; March 2001, Vol. 38 Issue: 2 p457-461, 5p
Abstrakt: 2Thioxo5,7dimethylpyrido2,3dpyrimidin43Hones 3were synthesized by the cyclocondensation of 2amino3carbethoxy4,6dimethylpyridine 1 with methylNaryldithiocarbamates 2and compared with the condensation between 1and aryl isothiocyanates 4. When a comparative study of N vs Salkylation of ambident 2thioxo5,7dimethylpyrido2,3dpyrimidin43Hones 3was carried out under liquidliquid and solidliquid phase transfer conditions using various alkylating agents 5, the Salkylated products 6were obtained exclusively and selectively.
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