| Autor: |
Palo, Outi M., Soronen, Pia, Silander, Kaisa, Varilo, Teppo, Tuononen, Katja, Kieseppä, Tuula, Partonen, Timo, Lönnqvist, Jouko, Paunio, Tiina, Peltonen, Leena |
| Zdroj: |
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics; April 2010, Vol. 153 Issue: 3 p723-735, 13p |
| Abstrakt: |
We performed a linkage analysis on 23 Finnish families with bipolar disorder and originating from the NorthEastern region of Finland, using the Illumina Linkage Panel IV 6K Array with an average intermarker spacing of 0.65 cM across the genome. We detected genomewide significant evidence for linkage of mood disorder bipolar disorder type I, II, or not otherwise specified, manic type of schizoaffective psychosis, cyclothymia, or recurrent depression to chromosomes 7q31 LOD 3.20 and 9p13.1 LOD 4.02. Analyzing the best markers on the complete set of 179 Finnish bipolar families supported the findings on chromosome 9p13 maximum LOD score of 3.02 at position 383 Mb, immediately upstream of the centromere. This region harbors several interesting candidate genes, including contactin associated proteinlike 3 CNTNAP3 and aldehyde dehydrogenase 1 ALDH1B1. For the 7q31 locus, only one extended pedigree and ten families originating from the same late settlement region in NorthEastern Finland provided evidence for linkage, suggesting that a gene predisposing to bipolar disorder is enriched in that region. Candidate genes of interest in this locus include potassiumvoltagegated channel, member 2 KCND2 and calciumdependent activator protein for secretion 2 CADPS2. The loci on the centromeric region of 9p13 and the telomeric region of 7q31 may represent susceptibility loci for mood disorder in the Finnish population. © 2009 WileyLiss, Inc. |
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