| Autor: |
Roosjen, Astrid, Šmisterová, Jarmila, Driessen, Cecile, Anders, Joachim T., Wagenaar, Anno, Hoekstra, Dick, Hulst, Ron, Engberts, Jan B. F. N. |
| Zdroj: |
European Journal of Organic Chemistry; April 2002, Vol. 2002 Issue: 7 p1271-1277, 7p |
| Abstrakt: |
Pyridinium amphiphiles have found practical application for the delivery of DNA into eukaryotic cells. A general synthetic method starting from (iso)nicotinoyl chloride has been devised for the preparation of pyridinium amphiphiles based on (bio)degradable esters, allowing structural variation both in the hydrophobic part and in the headgroup area. By means of differential scanning calorimetry, transmission electron microscopy and UV measurements, some characteristics, including hydrolytic behaviour, have been determined. In vitro transfection ability and toxicity have been determined using the eukaryotic COS-7 cell line. (© Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002) |
| Databáze: |
Supplemental Index |
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