Assignment of the 13C and 15N NMR spectra of the antitumour antibiotic streptonigrin

Autor: Anderberg, Pia I., Luck, Ian J., Harding, Margaret M.
Zdroj: Magnetic Resonance in Chemistry; April 2002, Vol. 40 Issue: 4 p313-315, 3p
Abstrakt: The assignments of the two pyridyl nitrogens and two amino nitrogens in the antitumour antibiotic streptonigrin, and all carbon resonances, were determined by 15N (HSQC, HMBC) and 13C (HSQC, HMBC) NMR techniques. These data provide useful probes for determination of the site(s) of metal complexation in the drug, which are important in the mechanism of antitumour activity. Copyright © 2002 John Wiley & Sons, Ltd.
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