| Autor: |
Martins de Sousa, Eduardo, Bonfim de Bortoli, Fernando, Amaral, Eduardo Pinheiro, Batista, Aline Carvalho, Liberman Kipnis, Thereza, Marques Cardoso, Alessandra, Kipnis, André, Junqueira-Kipnis, Ana Paula |
| Zdroj: |
Infection and Immunity; April 2010, Vol. 78 Issue: 4 p1571-1581, 11p |
| Abstrakt: |
Mycobacterium massiliense is an environmental opportunistic pathogen that has been associated with soft tissue infection after minor surgery. We studied the acute immune response of C57BL/6 and BALB/c mice infected intravenously with 106CFU of an M. massiliense strain isolated from a nosocomial infection in Brazil. The results presented here show that M. massiliense is virulent and pathogenic to both C57BL/6 and BALB/c mice, inducing a granulomatous inflammatory reaction that involves the activation of macrophages, dendritic cells, and natural killer cells induced by gamma interferon and interleukin-17 (IL-17) in C57BL/6 mice and by IL-12 in BALB/c mice. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
