| Autor: |
Ciruela, Francisco, Escriche, Marisol, Soloviev, Mikhail M., Canela, Enric I., Burgeño, Javier, Mallol, Josefa, Chan, Wai-Yee, Lluis, Carmen, McIlhinney, R.A. Jeffrey, Franco, Rafael |
| Zdroj: |
Drug Development Research; January/February 2001, Vol. 52 Issue: 1-2 p316-322, 7p |
| Abstrakt: |
Glutamate is the major excitatory neurotransmitter in the central nervous system and its function through ionotropic and metabotropic glutamate receptors can be modulated by other neurotransmitters/neuromodulators. Recently, evidence has emerged that seven transmembrane G-protein-coupled receptors (GPCRs) may be present as homo- and heteromers in the plasma membrane. Here we propose a new molecular and functional interaction between two unrelated types of GPCR, namely, the metabotropic glutamate type 1α and the adenosine A1 receptors in the central nervous system. Apart from providing a molecular basis for adenosine/glutamate receptor cross-talk, this interaction may lead to the development of novel reagents to treat neuropsychiatric disorders in which abnormal glutamatergic neurotransmission is involved. Drug Dev. Res. 52:316322, 2001. © 2001 Wiley-Liss, Inc. |
| Databáze: |
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