| Autor: |
Hellman, Bo, Gylfe, Erik, Berggren, Per-Olof, Andersson, Tommy, Abrahamsson, Håkan, Rorsman, Patrik, Betsholtz, Christer |
| Zdroj: |
UPSALA Journal of Medical Sciences; January 1980, Vol. 85 Issue: 3 p321-329, 9p |
| Abstrakt: |
The role of Ca2in the regulation of insulin secretion was evaluated using β-cell-rich pancreatic islets isolated from obob-mice. The glucose stimulation of the secretory activity is supposed to result from accumulation of Ca2in the submembrane cytoplasmic space. It is likely that this process reflects the balance between increased entry of Ca2into the β-cells and an enhanced sequestration of Ca2in the organelle sinks. The proposed model can explain the cAMP potentiation of glucose-stimulated insulin release with suppression of the mitochondrial Ca2uptake. Furthermore, differences in the Ca2buffering capacity of the secretory granules may account for other characteristic features of glucose-stimulated insulin release, in particular its biphasic nature and sensitivity to suppression on withdrawal of nutrients. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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