| Autor: |
Tasdemir, D., Mangalindan, G. C., Concepcion, G. P., Verbitski, S. M., Rabindran, S., Miranda, M., Greenstein, M., Hooper, J. N. A., Harper, M. K., Ireland, C. M. |
| Zdroj: |
Journal of Natural Products; February 2002, Vol. 65 Issue: 2 p210-214, 5p |
| Abstrakt: |
Two new isomalabaricane triterpenes, stellettin H (1) and stellettin I (2), have been isolated from the marine sponge Rhabdastrella globostellata, collected from the Philippines. Stellettins A−D (3−6), (−)-stellettin E (7), and rhabdastrellic acid-A (8) were also isolated and characterized. Stellettin B (4) and (−)-stellettin E (7) showed selective cytotoxicity toward p21WAF1/Cip1-deficient human colon tumor (HCT-116) cells with IC50 values of 0.043 and 0.039 μM, respectively. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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