Variants of the serotonin transporter gene and NEOPIR Neuroticism: No association in the BLSA and SardiNIA samplesHow to Cite this Article: Terracciano A, Balaci L, Thayer J, Scally M, Kokinos S, Ferrucci L, Tanaka T, Zonderman AB, Sanna S, Olla N, Zuncheddu MA, Naitza S, Busonero F, Uda M, Schlessinger D, Abecasis GR, Costa PT Jr. 2009. Variants of the Serotonin Transporter Gene and NEOPIR Neuroticism: No Association in the BLSA and SardiNIA Samples. Am J Med Genet Part B 150B:1070–1077.Paul T. Costa Jr receives royalties from the Revised NEO Personality Inventory. The authors declare that they have no other competing interests.

Autor: Terracciano, Antonio, Balaci, Lenuta, Thayer, Jason, Scally, Matthew, Kokinos, Sarah, Ferrucci, Luigi, Tanaka, Toshiko, Zonderman, Alan B., Sanna, Serena, Olla, Nazario, Zuncheddu, Maria Antonietta, Naitza, Silvia, Busonero, Fabio, Uda, Manuela, Schlessinger, David, Abecasis, Gonçalo R., Costa, Paul T.
Zdroj: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics; December 2009, Vol. 150 Issue: 8 p1070-1077, 8p
Abstrakt: The polymorphism in the serotonin transporter gene promoter region 5HTTLPR is by far the most studied variant hypothesized to influence Neuroticismrelated personality traits. The results of previous studies have been mixed and appear moderated by the personality questionnaire used. Studies that used the TCI to assess Harm Avoidance or the EPQ to assess Neuroticism have found no association with the 5HTTLPR. However, studies that used the NEOPIR or related instruments NEOPI, NEOFFI to measure Neuroticism have found some evidence of association. This study examines the association of variants in the serotonin transporter gene in a sample from a genetically isolated population within Sardinia Italy that is several times larger than previous samples that used the NEOPIR N  3,913. The association was also tested in a sample N  548 from the Baltimore Longitudinal Study of Aging BLSA, in which repeated NEOPIR assessments were obtained. In the SardiNIA sample, we found no significant association of the 5HTTLPR genotypes with Neuroticism or its facets Anxiety, AngryHostility, Depression, SelfConsciousness, Impulsiveness, and Vulnerability. In the BLSA sample, we found lower scores on Neuroticism traits for the heterozygous group, which is inconsistent with previous studies. We also examined eight SNPs in the SardiNIA N  3,972 and nine SNPs in the BLSA N  1,182 that map within or near the serotonin transporter gene SLC6A4, and found no association. Along with other large studies that used different phenotypic measures and found no association, this study substantially increases the evidence against a link between 5HTT variants and Neuroticismrelated traits. © 2009 WileyLiss, Inc.
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