Poly-N-Acetyl Glucosamine as a Scaffold for Cartilage Tissue Engineering in Nude Mice

Autor: Hill, Christopher M., An, Yuehuei H., Kang, Qian K., Demcheva, Marina V., Whitson, S.William, Vournakis, John
Zdroj: Key Engineering Materials; June 2005, Vol. 288 Issue: 1 p71-74, 4p
Abstrakt: Athymic nude mice were used as an animal model to evaluate the chondrogenic effects of bovine fetal chondrocytes seeded onto a new poly-N-acetyl glucosamine sponge. Results show excellent hyaline-like cartilage formation with high glycosaminoglycan concentration after 6 weeks. At 4 weeks there is less cartilage formation and more fibrous tissue infiltrate. Although further studies are needed, these initial data support the use of poly-N-acetyl glucosamine sponge as a scaffold for cartilage tissue engineering.
Databáze: Supplemental Index