| Autor: |
Takeuchi, Akari, Ohtsuki, Chikara, Kamitakahara, Masanobu, Ogata, Shinichi, Tanihara, Masao, Miyazaki, Toshiki, Yamazaki, Masao, Furutani, Yoshiaki, Kinoshita, Hisao |
| Zdroj: |
Key Engineering Materials; April 2005, Vol. 284 Issue: 1 p329-332, 4p |
| Abstrakt: |
Porous a-tricalcium phosphate (a-TCP) ceramics are attractive as a novel bioresorbable material for bone repair, since they can be easily fabricated through conventional sintering of b-TCP at high temperature. However, the solubility of a-TCP is too high to keep its body until the bone defect is repaired completely. Coating of the a-TCP porous body with organic polymer is a way to reduce the degradation rate. In the present study, biodegradation of a-TCP porous body coated with silk sericin was evaluated in vivo. Bone repair at the defect made in rabbit tibia was nearly completed after 4 weeks. Higher density of cortical bone was estimated for a-TCP coated with sericin than for mere a-TCP. The a-TCP porous body coated with sericin is expected as a material that show less degradation than mere a-TCP, and may result in suitable bone repair. |
| Databáze: |
Supplemental Index |
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