Metabolism and nephrotoxicity of tetralin in male Fischer 344 rats
| Autor: | Serve, M. P., Llewelyn, B. M., Yu, K. O., McDonald, G. M., Olson, C. T., Hobson, D. W. |
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| Zdroj: | Journal of Toxicology and Environmental Health Part A; March 1989, Vol. 26 Issue: 3 p267-275, 9p |
| Abstrakt: | Tetralin, a component of fuels, solvents, and varnishes, is metabolized in male Fischer 344 rats to 1-tetralol, 2-tetralol, 2-hydroxyl-1-tetralone, 4-hydroxyl-1-tetralone, 1,2-tetralindiol, and 1,4-tetralindiol. Rats treated with tetralin demonstrated the classic lesions of hydrocarbon-induced nephropathy. |
| Databáze: | Supplemental Index |
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