| Autor: |
Hanson, R. L., Henderson, T. R., Hobbs, C. H., Clark, C. R., Carpenter, R. L., Dutcher, J. S., Harvey, T. M., Hunt, D. F. |
| Zdroj: |
Journal of Toxicology and Environmental Health Part A; April 1983, Vol. 11 Issue: 4-6 p971-980, 10p |
| Abstrakt: |
Mutagenic and nonmutagenic extracts of fly ash from fluidlzed bed combustion were analyzed to determine the compounds responsible for the direct mutagenic activity (mutagenic activity that does not require added metabolic enzymes in the Salmonella mutogenicity assay). Some nitro derivatives of polycyclic aromatic hydrocarbons which are direct acting mutagens were detected by tandem triple quadrupole mass spectrometry. Treatment of a mutagenic and a nonmutagenic extract with excess N2O4 resulted in 28- and 3200-fold increases, respectively, in direct mutagenicity in Salmonella typhimurium strain TA98 and an increase in the relative abundance of nitroaromatic compounds. Polycyclic aromatic compounds were also detected and tentatively identified by gas chromatography-mass spectrometry. Since, previous studies have shown that polycyclic aromatic hydrocarbons may react with NO2 to form direct-acting mutagens, it appears that the direct-acting mutagens in these fly ash extracts may be products of reactions of polycyclic aromatic hydrocarbons with NOX in the combustion gases. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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