| Autor: |
Tan, Eng-Lay, Brimer, Patricia, Schenley, Robert, Hsie, Abraham |
| Zdroj: |
Journal of Toxicology and Environmental Health Part A; March 1983, Vol. 11 Issue: 3 p373-380, 8p |
| Abstrakt: |
It has recently been shown that coal fly ash collected from coal-fired plants contains dimethyl sulfate (DMS) and monomethyl sulfate (MS) at concentrations as high as 830 ppm. Both these compounds were tested in the CHO/HGPRT system, and it was found that only DMS was cytotoxic and mutagenic to CHO cells. On a molar basis, DMS is twice as mutagenic as methyl methanesulfonate (MMS). Under our treatment conditions, maximum mutation induction and cytotoxicity were obtained after approximately 1 h. The mutagenic potency of DMS was more stable in aqueous solutions at 4°C than at the ambient temperature of 22°C, but was least stable in DMSO solutions at 22°C Near-ultraviolet (near-UV) light caused an approximately twofold decrease in the mutagenic and cytotoxic effects of DMS. Although DMS produced by coal combustion could be rendered innocuous by environmental agents in a short span of time, this compound could still pose a health risk to workers closely involved in coal-combustion technology. |
| Databáze: |
Supplemental Index |
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