| Autor: |
Jensen, Ole Kudsk, Rasmussen, Claus, Mollerup, Frank, Christensen, Peder Bjerg, Hansen, Henrik, Ekelund, Suzanne, Thulstrup, Ane Marie |
| Zdroj: |
Journal of Rheumatology; August 2002, Vol. 29 Issue: 8 p1615-1618, 4p |
| Abstrakt: |
OBJECTIVE: To examine the effect of methotrexate (MTX) and folic acid supplementation on the homocysteine level in patients with rheumatoid arthritis (RA). METHODS: A cross sectional study was performed in 81 patients with RA, comprising a standardized clinical interview, an examination, and a blood specimen test. RESULTS: P-homocysteine tended to be lower in 41 patients receiving MTX, compared with 40 patients not receiving MTX. Of the MTX treated patients, 76% received folic acid supplementation. Multivariate analysis revealed a statistically significant association between P-homocysteine and P-creatinine (p < 0.001), and disease activity/progression measured by the Health Assessment Questionnaire score (p < 0.001). There was a tendency to negative association between P-homocys-teine and folic acid supplementation. CONCLUSION: P-homocysteine in patients with RA receiving MTX and folic acid supplementation did not differ significantly from P-homocysteine in RA patients receiving other types of treatment. |
| Databáze: |
Supplemental Index |
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