| Autor: |
Chao, E. Y., Minick, D. J., Sternbach, D. D., Shearer, B. G., Collins, J. L. |
| Zdroj: |
Organic Letters; February 2002, Vol. 4 Issue: 3 p323-326, 4p |
| Abstrakt: |
A solid-phase synthesis of substituted benzopyranoisoxazoles is described. The six-step synthesis features a novel method of generating nitrile oxides on a polymer support followed by an intramolecular 1,3-dipolar cycloaddition with a tethered alkyne for assembly of the benzopyranoisoxazole scaffold. Furthermore, the utilization of single-bead attenuated total reflectance Fourier transform infrared (ATR-IR) microspectroscopy as an essential analytical tool for reaction optimization is highlighted. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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