| Autor: |
Heiberg, Elisabeth, Nalesnik, W. J., Janney, C. |
| Zdroj: |
Acta Radiologica; March 1991, Vol. 32 Issue: 2 p174-177, 4p |
| Abstrakt: |
The effects of different voltages and dosages during direct current treatment were studied to determine the most effective tumor treatment. Groups of nude mice with subcutaneous human colon cancer nodules were treated with a single electrolytic dose (charge) of direct current using two percutaneously placed needle electrodes. All the treated groups responded and the residual tumor volumes were significantly lower (p< 0.001) than the control group. 7.5 V gave the greatest tumor reduction, significantly more than for 12.5, 10.0,and 2.5 V. 35 Cml of tumorwas more effective than 30 Cml (p<0.05) and no difference in response wasobtained between 35 and 50 Cml. Hyperthermia did not appear to play a significant part in direct current treatment in the examined voltage range as no intra-tumoral temperature elevation was observed. Direct current may allow effective percutaneous treatment of metastases which are unresponsive or unsuitable for conventional treatment. |
| Databáze: |
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