| Autor: |
Banville, Jacques, Lapointe, Philippe, Belleau, Bernard, Menard, Marcel |
| Zdroj: |
Canadian Journal of Chemistry; June 1988, Vol. 66 Issue: 6 p1390-1399, 10p |
| Abstrakt: |
The preparation of 6α-methyl-2-methyl-6β-phenoxyacetamidopenem-3-carboxylate, 6α-methoxy-2-methyl-6β-phenoxyacetamidopenem-3-carboxylate, and 6α-methoxy-2-methyl-6β-phenylmalonylamidopenem-3-carboxylate from penicillin V and 6-aminopenicillanic acid is described. These penems have been isolated and characterized as their sodium or potassium salt. The chemical stability of the above compounds was determined as their half-life in aqueous buffer. In this way, it was found that the 6α-methyl analog was more stable than the parent 6-monosubstituted acylaminopenem while the remaining analogs were of comparable stability. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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