| Autor: |
Bick, P. H., Brown, A. C. G., Marsden, H., Smith, H. W., Tamura, R. N., Zwickl, C. M. |
| Zdroj: |
Animal Biotechnology; 1990, Vol. 1 Issue: 1 p61-71, 11p |
| Abstrakt: |
Antibody responses to recombinant bovine somatotropin were followed over three lactations in Jersey, Meuse-Rhine-Issel and Friesian cows. Randomized blocks of animals were observed during a pretreatment period and were given 320, 640-or 960 mg of recombinant somatotropin (somidobove) at 28 day intervals through the lactation period or left untreated. All treated animals developed a detectable antibody response to somidobove. These responses peaked at 45-50 relative μg/ml as compared to pretreatment levels of 10-25 relative μg/ml. A normal antibody response level is 1000-4000 μg/ml. The antibody level returned to baseline values when treatment was discontinued and remained at baseline until treatment was resumed during the next lactation. Treated cows did not develop an anamnestic response during the second and third lactations when the antibody responses peaked at 38 and 27 relative μg/ml respectively. Antibody responses to somidobove were analyzed in calves born of cows that received somidobove treatment. Anti-somidobove antibody was detectable in the calves at 10-13 relative μg/ml but these levels were indistinguishable from the antibody levels found in calves born of untreated cows. Calves that received milk from somidobove treated cows demonstrated anti-somidobove levels within the normal range of control calves ( < 8 relative μg/ml). These data demonstrate that somidobove supplementation is associated with the induction of a very low level antibody response that stabilizes at a low level, decreases over time and does not give a secondary response. These antibodies are not associated with adverse health effects or interference with the biological effects of somidobove. There were no immunological consequences to the calves born of somidobove treated cows or calves that receive milk from treated cows. |
| Databáze: |
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