| Autor: |
Lerman, Jerrold, Strong, H Andrew, LeDez, Kenneth M, Swartz, Jo, Rieder, Michael J, Burrows, Frederick A |
| Zdroj: |
Clinical Pharmacology & Therapeutics; August 1989, Vol. 46 Issue: 2 p219-225, 7p |
| Abstrakt: |
We determined the effect of age on the serum concentration of α1-acid glycoprotein (α1-AGP) in venous blood from 134 subjects who ranged in age from preterm neonates to 18-year-old adolescents. The mean (± SD) serum concentration of α1-AGP, determined by radial immunodiffusion, increased significantly with age: the concentration found in neonates was less than that found in infants which, in turn, was less than that found in older children (p < 0.001). In addition, we determined the effect of α1-AGP on the free fraction of lidocaine in four groups of infants and children who received intravenous lidocaine (1.5 mg/kg). The percentage of free lidocaine correlated inversely and linearly with the serum α1-AGP concentration (r2= 0.617; p < 0.001). The percentage of free lidocaine in the five neonates exceeded that in the older age groups. We conclude that the serum concentration of α1-AGP increases while the free fraction of lidocaine decreases from early infancy to adolescence. |
| Databáze: |
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