| Autor: |
MUJER, CESAR V., WAGNER, MARY ANN, ESCHENBRENNER, MICHEL, HORN, TROY, KRAYCER, JO ANN, REDKAR, RAJENDRA, HAGIUS, SUE, ELZER, PHILIP, DELVECCHIO, VITO G. |
| Zdroj: |
Annals of the New York Academy of Sciences; October 2002, Vol. 969 Issue: 1 p97-101, 5p |
| Abstrakt: |
Brucella melitensisis a facultative, intracellular, gram-negative cocco-bacillus that causes Malta fever in humans and brucellosis in animals. There are at least six species in the genus, and the disease is classified as zoonotic because several species infect humans. Using 2-D gel electrophoresis and mass spectrometry, we have initiated (i) a comprehensive mapping and identification of all the expressed proteins of B. melitensisvirulent strain 16M, and (ii) a comparative study of its proteome with the attentuated vaccinal strain Rev 1. Comprehensive proteome maps of all six Brucellaspecies will be generated in order to obtain vital information for vaccine development, identification of pathogenicity islands, and establishment of host specificity and evolutionary relatedness. |
| Databáze: |
Supplemental Index |
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